Fresh analysis indicates that patients who come off popular slimming jabs like Mounjaro or Wegovy can put back on reduced body mass much more quickly than those who end traditional lifestyle plans.
Findings released in a leading medical journal points out that while obese people often shed a large proportion of their body weight while using the jabs, the mass comes back at an estimated rate of nearly a kilo each month upon discontinuation.
"People buying such treatments must be aware of the risk of rapid weight regain when the medication ends," stated expert Dr. Susan Jebb.
This pace of recovery suggests a reversion to pre-treatment mass within about a year and a half.
Analyzing Therapies
The study, which looked at 37 of studies involving over 9,000 of participants, compared the effects of these new drugs with conventional dieting.
The team point out that individuals who lose weight through lifestyle changes alone typically have a less rapid weight regain—approximately 100 grams monthly—after stopping.
Understanding the Quick Rebound
Nutrition scientists propose the mechanism of the drugs accounts for the heightened regain.
The injections mimic a body's own chemical called glucagon-like peptide-1, which controls appetite.
"Artificially providing GLP-1 concentrations far above than normal might result in the body to generate a reduced amount of its own natural hormone, and may also reduce responsiveness to its actions," said Dr. Adam Collins, a nutrition specialist.
"Withdrawal of this medication leads to hunger is no longer kept in check, making overeating a significant risk."
A Chronic Disease?
Health authorities advise the injections for people with weight-linked health risks, alongside prescribed diet and exercise modifications.
A number of clinicians argue that, due to the likelihood of weight regain, the therapy should be considered long-term.
This opinion is supported by pharmaceutical companies, who state that the results "underscore the chronic nature of obesity," comparing it to managing conditions like high blood pressure.
Patient Accounts
People who have stopped the jabs report a sudden resurgence of cravings.
"It felt as if something flipping and you're instantly ravenous," described a patient.
This challenge is compounded if users have not developed permanent dietary or behavioural modifications during therapy.
Widespread Interest
Recent estimates show that a significant number of adults in the UK have tried weight-loss jabs in the last 12 months, with demand continuing to grow.
- Adoption is greater among women than males.
- The 40s and 50s demographic shows the highest usage rates.
- Many obtain the medications through private healthcare rather than the NHS.
In conclusion, clinicians stress that while the jabs are potent agents for shedding pounds, they are not a standalone solution and long-term success likely depends on integrated lifestyle management.
